Different claims regarding other the causes of depression have circulated for decades. As our understanding of depression has changed, so has our ability to treat this widespread mental health disorders. Some claim that neurotransmitters—serotonin and norepinephrine—play the largest role in regulating mood. Others look to the glutamate system. And still, one recent claim, which has grown in popularity, is that depression is gut-related.
The history of ketamine goes back to 1962, when it was first synthesized by American scientist, Calvin Stevens, at the Parke Davis Laboratories. The drug was known as a fast acting anesthetic and, eventually, a recreational hallucinogen. However, in the late 1990s, its antidepressive benefits were discovered. Research performed over the last two decades suggests that ketamine infusions could rapidly and effectively ease symptoms of depression and anxiety in up to 70% of patients, a discovery which marked the beginning of ketamine clinics popping up all over the country.
There is no one-size-fits-all solution for depression. Even though 17% of people will suffer from depression over the course of their lives, modern medicine is still searching for a comprehensive solution. Traditional antidepressant medications are the first line of treatment for depression, though they are only effective for about 40-70% of patients, depending on what source you quote. In recent years, ketamine infusions have emerged as one of the most effective depression treatment available, offering hope for even the most debilitating cases of depression and providing relief to 70% of patients. Inspired by the way ketamine works to treat depression, several pharmaceutical companies are well underway developing new medications that may revolutionize the way we treat this mental health disorder.
The importance of diagnosing and treating mental health disorders is incontestable: with the country’s suicide rate growing at a faster rate than ever—and with a number of celebrity suicides bringing much-needed awareness to the matter—there is no argument that mental wellbeing is an important health concern that deserves our attention and care. However, the physical implications of depression and anxiety are much less talked about—even though a new study shows that they can be as severe as the health concerns caused by obesity or smoking.
When it comes to depression, no one is exempt—especially those at the tops of their industries. In fact, as a result of the stress that goes hand-in-hand with their careers, plus the personal characteristics that have enabled them to become successful in the first place, C-level executives, business leaders and entrepreneurs are perhaps more susceptible to depression than other people.
The mind-altering effects of psychedelic drugs may do more than just change a person’s state of consciousness. In a new study recently published in Cell Reports, researchers at the University of California, David found that substances such as LSD, DMT and MDMA actually increased the number of neural connections between brain cells. These findings could ultimately be used to repair the damaged neural connections oftentimes observed in those suffering from depression, anxiety, PTSD, and other psychiatric disorders.