Using ketamine as a treatment for major depression is a relatively new practice. While ketamine has been used as an anesthetic since the 1960s, its application as a depression treatment didn’t start to attract attention from researchers until 2006, with the first ketamine infusion clinics opening in the US around 2012. With a 70% success rate in improving the symptoms of depression, ketamine infusions have become increasingly popular, bringing hope to those who had none.
In the United States, intravenous ketamine infusions have emerged as the primary route of administration for the treatment of depression. However, there are other ways to take ketamine, including orally with ketamine pills for depression, sublingually, nasally, or intramuscularly. Each route of administration offers its own unique benefits.