OCD Treatment in Littleton, CO
Explore physician-led IV ketamine therapy for obsessive-compulsive disorder when intrusive thoughts, compulsions, checking, avoidance, or reassurance-seeking continue to interfere with daily life despite previous treatment.
Physician-Led OCD Care Serving Littleton and South Denver
At Vitalitas, we understand that obsessive-compulsive disorder can take up significant time and mental energy, even when you recognize that a thought, fear, or ritual does not reflect what you actually want. At our Littleton clinic at 26 West Dry Creek Circle, Suite 200, Littleton, CO 80120, we review your symptoms, mental health history, medications, previous treatment, safety factors, and goals before determining whether IV ketamine therapy may be appropriate for your care.
When OCD Becomes Difficult to Manage
Obsessive-compulsive disorder (OCD) is a long-lasting mental health condition involving obsessions, compulsions, or both. Obsessions are recurring, unwanted thoughts, urges, or mental images. Compulsions are repetitive behaviors or mental acts a person feels driven to perform, often in response to an obsession. OCD symptoms can be time-consuming, cause significant distress, and interfere with daily life.
OCD may involve patterns such as:
Intrusive or unwanted thoughts, images, or urges
Repeated checking or reassurance-seeking
Cleaning or washing rituals
Counting, repeating, or arranging behaviors
Avoidance of situations that trigger obsessions
Compulsions that may temporarily reduce anxiety while reinforcing the cycle
OCD is different from simply liking order, having routines, or occasionally double-checking something. Symptoms can become difficult to interrupt and may affect concentration, relationships, work, school, sleep, and everyday routines.
Established OCD treatment commonly includes psychotherapy, medication, or a combination of approaches. Exposure and response prevention (ERP), a specific form of cognitive behavioral therapy, is an evidence-based treatment for OCD.
When OCD symptoms remain difficult to manage despite previous care, some patients may explore additional treatment options.
IV Ketamine Therapy for OCD
At Vitalitas, we provide physician-led IV ketamine therapy for selected patients with OCD.
Ketamine is FDA-approved for induction and maintenance of general anesthesia. Its use for OCD and other psychiatric conditions is off-label, meaning ketamine has not been FDA-approved specifically to treat obsessive-compulsive disorder. The FDA provides additional context on the current use of ketamine in emerging areas of therapeutic interest.
Ketamine is an NMDA receptor antagonist that affects glutamate signaling in the brain. Researchers have studied whether this mechanism may have therapeutic relevance for OCD.
The evidence is still developing. A 2026 systematic review of ketamine for OCD identified five eligible studies, including three randomized controlled trials and two open-label trials. The studies varied in route of administration, dosing frequency, and treatment design. The authors concluded that additional research is needed to better understand how ketamine treatment may be optimized for sustained symptom reduction.
We approach ketamine accordingly. IV ketamine is not a cure for OCD, and it does not replace established OCD treatment when psychotherapy, psychiatric care, or medication management remains appropriate. Instead, ketamine may be considered as an additional off-label option for some patients after careful evaluation.
Learn more about our broader approach to ketamine therapy for OCD.
Careful Screening and Physician-Led Ketamine Treatment
OCD symptoms can look very different from one person to another, so a diagnosis alone does not determine whether ketamine therapy is appropriate.
Before recommending treatment, we consider your:
OCD symptoms and how they affect daily life
Mental health and medical history
Current medications
Previous treatment
Clinical stability and safety factors
Treatment goals and expectations
If IV ketamine treatment moves forward, our care model includes:
Individualized planning based on your symptoms, history, previous care, and clinical needs
Physician oversight throughout treatment
Clinical monitoring of heart rate, heart rhythm, blood pressure, oxygen level, and how you are feeling during the infusion
Follow-up to review your response and guide future treatment decisions
Care coordination with the clinician managing your mental health treatment when appropriate
Not everyone with OCD will be a candidate for ketamine therapy. We believe careful screening, realistic expectations, and consideration of your broader OCD treatment plan are essential parts of responsible care.
What to Expect From Ketamine Treatment for OCD
Ketamine therapy at Vitalitas begins with a clinical consultation. We review what you have been experiencing, your health history, medications, previous treatment, goals, and whether outpatient ketamine treatment can be provided safely and appropriately.
If treatment is recommended, IV ketamine is administered in a private room with physician oversight and clinical monitoring. Mental health infusions at Vitalitas are typically about 40 minutes, with treatment decisions individualized according to your response, tolerance, safety, and clinical needs.
You will need transportation home after an infusion. For the remainder of the treatment day, you should avoid driving, operating heavy machinery, alcohol, intense work, and major decisions.
Follow-up is part of the treatment process. We review your response and overall progress before making decisions about continued care. When appropriate, we also coordinate with the clinician already managing your mental health treatment.
OCD Treatment at Our Littleton Clinic
Our Littleton clinic provides physician-led IV ketamine therapy for selected patients with OCD and serves patients from Littleton and the south Denver Metro area, including Highlands Ranch, Centennial, Englewood, and South Denver.
Vitalitas Littleton
26 West Dry Creek Circle, Suite 200, Littleton, CO 80120
Learn more about our Littleton clinic.
If intrusive memories, avoidance, hypervigilance, sleep disruption, or other PTSD symptoms remain difficult to manage despite previous treatment, we can help you understand whether an evaluation for off-label IV ketamine therapy may be an appropriate next step.
Frequently Asked Questions About Ketamine for OCD
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No. Ketamine is FDA-approved for induction and maintenance of general anesthesia, but its use for OCD and other psychiatric conditions is off-label. We explain that distinction during the evaluation process so you can consider treatment with clear expectations.
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Ketamine should not be considered a replacement for exposure and response prevention, psychotherapy, psychiatric care, or medication management when those treatments are appropriate. We consider ketamine within the context of your broader OCD treatment plan.
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Ketamine may be considered for selected patients whose OCD symptoms remain difficult to manage despite previous treatment. Candidacy depends on your symptoms, treatment history, medications, medical and mental health history, clinical stability, safety profile, and whether outpatient ketamine treatment is appropriate.
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No. Ketamine is not a cure for obsessive-compulsive disorder, and response varies from person to person. Research into ketamine for OCD is still developing. We evaluate your response before making decisions about continued care.
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Mental health infusions at Vitalitas are typically about 40 minutes. Your overall treatment plan is individualized according to your clinical needs, response, tolerance, and safety.
Request an OCD Treatment Consultation in Littleton
If OCD continues to take up significant time, limit your daily routines, or remain difficult to manage despite previous care, we can help you understand what physician-led IV ketamine therapy involves and whether this off-label treatment may fit your care needs.
Our process begins with careful evaluation, clear information, and an individualized clinical recommendation.
Medical Disclaimer
This page is for general educational purposes and is not a substitute for medical advice, diagnosis, or individualized treatment. Ketamine use for OCD and other psychiatric conditions is off-label. Treatment decisions should be made with a qualified healthcare professional after an appropriate evaluation.
Scientific Resources
Obsessive-Compulsive Disorder: When Unwanted Thoughts or Repetitive Behaviors Take Over — National Institute of Mental Health.
Understanding Current Use of Ketamine for Emerging Areas of Therapeutic Interest — U.S. Food and Drug Administration, 2024.
Ketamine for the Treatment of Obsessive-Compulsive Disorder (OCD): A Systematic Review on Efficacy and Tolerability — Clinical Neuropharmacology, 2026.

